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產品描述： HA130 is a selective autotaxin (ATX) inhibitor with an IC50 of 28 nM. |
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靶點：
Autotaxin:28 nM (IC50);PDE |
體內研究：
HA130 slows T cell migration across lymph node HEVs. HA130 decreases the outside HEVs/inside HEVs ratio by 3-4-fold compared to vehicle-treated animals vehicle. The s.c. administration of HA130 induces marked lymphocyte accumulation within the endothelial cell (EC) and sub-EC layers of HEVs in draining lymph nodes (LNs) |
參考文獻：
1. Zhang Y, et al. Autotaxin through lysophosphatidic acid stimulates polarization, motility, and transendothelial migration of naive T cells. J Immunol. 2012 Oct 15;189(8):3914-3924. 2. Bai Z, et al. Constitutive lymphocyte transmigration across the basal lamina of high endothelial venules is regulated by theautotaxin/lysophosphatidic acid axis. J Immunol. 2013 Mar 1;190(5):2036-2048. |
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溶解性：
DMSO : ≥ 39 mg/mL (84.18 mM) |
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保存條件：
2-8℃ |
配置溶液濃度參考：
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1mg |
5mg |
10mg |
| 1 mM |
2.158 ml |
10.792 ml |
21.585 ml |
| 5 mM |
0.432 ml |
2.158 ml |
4.317 ml |
| 10 mM |
0.216 ml |
1.079 ml |
2.158 ml |
| 50 mM |
0.043 ml |
0.216 ml |
0.432 ml |
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| 注意： |
部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。 |
上海工商
危險品化學品經營許可證（不帶存儲）
營業(yè)執(zhí)照(三證合一)
北京